发明名称 |
CLONING AND CHARACTERIZATION OF THE CELL DEATH GENES CED-3 AND CED-4 |
摘要 |
Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally related cell death genes from various organisms; methods and agents for altering (increasing or decreasing) the activity of the cell death genes and, thus, of altering cell death; and uses therefor. Specifically, two genes shown to be essential for almost all of the cell deaths which occur in the development of C. elegans, referred to as ced-3 and ced-4, have been cloned, sequenced and characterized. |
申请公布号 |
WO9325685(A1) |
申请公布日期 |
1993.12.23 |
申请号 |
WO1993US05701 |
申请日期 |
1993.06.14 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
HORVITZ, H., ROBERT;YUAN, JUNYING;SHAHAM, SHAI |
分类号 |
A61K38/00;C07K14/435;C07K14/47;C12N9/64;C12N15/12;(IPC1-7):C12N15/12;C12N15/11;C12Q1/68;A61K37/02;A61K31/70;G01N33/577;C07K13/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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