The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.
申请公布号
WO9325687(A1)
申请公布日期
1993.12.23
申请号
WO1993US05548
申请日期
1993.06.09
申请人
CHIRON CORPORATION;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
