| 发明名称 |
A NOVEL ENDOTHELIAL CELL MOLECULE MEDIATING LYMPHOCYTE BINDING IN MAN |
| 摘要 |
A novel endothelial cell molecule, VAP-1, that mediates lymphocyte binding in man, is described. Anti-VAP-1 monoclonal antibodies are described and the monoclonal antibody 1B2 is provided by this invention, as well as the hybridoma cell line (DSM ACC2041) which produces it. This invention further provides methods for the treatment of inflammatory and autoimmune diseases by the administration of VAP-1 binding compounds, such as anti-VAP-1 antibodies. |
| 申请公布号 |
WO9325582(A1) |
申请公布日期 |
1993.12.23 |
| 申请号 |
WO1993FI00250 |
申请日期 |
1993.06.09 |
| 申请人 |
JALKANEN, SIRPA;SALMI, MARKO |
发明人 |
JALKANEN, SIRPA;SALMI, MARKO |
| 分类号 |
G01N33/53;A61K38/00;A61K39/395;A61P1/00;A61P17/00;A61P19/02;A61P29/00;A61P31/00;A61P31/04;A61P37/00;A61P37/02;A61P43/00;C07K14/47;C07K14/705;C07K14/78;C07K16/00;C07K16/18;C07K16/28;C12N5/10;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/577;(IPC1-7):C07K15/00 |
主分类号 |
G01N33/53 |
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