<p>Neoplastic and other diseases can be diagnosed by assaying a human test sample e.g. body fluid, tissue or cultured tumour explant cells, for structurally altered or abnormally expressed growth factor receptors or for the mRNA transcripts of genes which encode them. Antibodies capable of binding a predetermined amino acid sequence within the EGF receptor are also useful in diagnosis and therapy as are conjugates of an immunogenic polymer bound to a polypeptide fragment of EGF receptor. DNA and RNA encoding EGF receptor or fragments thereof are also described.</p>
申请公布号
DE3587657(D1)
申请公布日期
1993.12.23
申请号
DE19853587657
申请日期
1985.01.30
申请人
IMPERIAL CANCER RESEARCH TECHNOLOGY LTD., LONDON, GB
发明人
WATERFIELD, MICHAEL, D. IMPERIAL CANCER, LONDON WC2A 3PX, GB;SCHLESSINGER, J., REHOVOT, IL;ULLRICH, AXEL, SOUTH SAN FRANCISCO, CA 94080, US