TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS

摘要

Compounds of formula (1) are described wherein Y represents a halogen atom or a group -OR<1> where R<1> represents an optionally substituted alkyl group; R<2> represents an optionally substituted cycloalkyl, cycloalkenyl or polycycloalkyl group; Z represents -N(R<3>)CO- or -CONE(R<3>) represents a hydrogen atom or an alkyl, aryl or aralkyl group; R<4> represents an aryl or heteroaryl group; X represents -O-, -S-, -CH2- or -N(R<5>)-, where R<5> is a hydrogen atom or an alkyl group; n is zero or an integer or value 1, 2 or 3; and the salts, solvates and hydrates thereof. The compounds are selective phosphodiesterase IV inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases.