| 摘要 |
A following dipeptide derivative of the following formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. <IMAGE> (I) wherein: R1 is C1-C12 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, aryl, or heterocyclic radical; R2 is carbamoyl, aryl, 5- or 6-membered heterocyclic radical, C1-C12 alkyl-S-, C1-C12 alkyl-S-CH2-, or C3-C10 cycloalkyl-S-; R3 is aryl or 5- or 6-membered heterocyclic radical; R4 is R4'-SO2 or R4'-CO; R4' is aryl, C1-C12 alkyl, C2-C6 alkenyl, C2-C6 alkynyl; C3-C10 cycloaklyl, or heterocyclic radical; X is CH2, NH, O, or S; and Y is CO or NHSO2, wherein R1, R2, R3 and R4' each may be substituted with one to three substituents.
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