5-AMINOQUINOLONECARBOXYLIC ACID DERIVATIVE AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT

摘要

A 5-aminoquinolonecarboxylic acid derivative represented by general formula (1) or a salt thereof, and an antibacterial containing the same as the active ingredient, wherein R<1> represents hydrogen, amino, C1-C5 linear or branched alkyl, or an alkylamino group having a C1-C5 linear or branched alkyl group; R<2> represents hydrogen or C1-C5 linear or branched alkyl; X represents halogen; Y represents CH2, NH, CHR<3>, NR<3> (wherein R<3> represents C1-C5 linear or branched alkyl) or oxygen; and Z represents an oxygen atom or two hydrogen atoms. It has a potent antibacterial activity against gram-positive bacteria including resistant strains and can be well absorbed in living organisms.