发明名称 |
USE OF CARDIOTONIC DRUGS AND INHIBITORS OF NITRIC OXIDE SYNTHESIS TO ALLEVIATE PATHOLOGIC HYPOTENSION |
摘要 |
The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines, IFN, TNF, IL-1 or IL-2 and the like. Said method involves administering, preferably intravascularly, a therapeutically effective amount of dobutamine and an inhibitor of nitric oxide formation from arginine. Although preferable administration is intravascular, it is contemplated that other parenteral administration routes such as intraperitoneal, intramuscular or subdermal injection, for example, may prove useful. Enteral or topical administration of arginine analogs may also prove beneficial under certain clinical conditions. |
申请公布号 |
WO9324122(A1) |
申请公布日期 |
1993.12.09 |
申请号 |
WO1993US04940 |
申请日期 |
1993.05.25 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
KILBOURN, ROBERT, G.;GROSS, STEVEN, S.;GRIFFITH, OWEN, W. |
分类号 |
C07D401/04;A61K31/135;A61K31/195;A61K31/198;A61K31/223;A61K31/44;A61K31/4427;A61P3/00;A61P9/02;A61P9/04;(IPC1-7):A61K31/195 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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