t-PA MODIFICATION

摘要

A tissue plasminogen activator (t-PA) modification prepared by inserting a spacer comprising an oligopeptide composed of several to tens of amino acid residues into a single-strand cleavage site of t-PA. When it is in the form of a single strand, it is lowly active and resistant to plasminogen activator inhibitor 1. When converted into the form of a double strand at a thrombotic part of a patient, it has an activity substantially equivalent to that of natural t-PA. Accordingly, it is remarkably excellent as a therapeutic thrombolytic agent, because it has an efficacy substantially equivalent to that of natural t-PA even in a smaller dose and has less side effects.