发明名称 BIPHENYLABKÖMMLINGE, VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG.
摘要 Biphenyl-2,2'-dicarboxylic acid derivs. of formula (I) are new where R1 and R2 are H or methyl. A gallate deriv. of formula (II; X=Y=H; R3 = H, Me, Et or propyl) is halogenated to (II, X=Y= halogen) then dehalogenated (e.g. with zinc) to (II, X= halogen, Y=H). This after methylation and Ullmann condensn. gives cpd. (III, Z=H) which is oxidised with lead tetraacetate, to cpd. (III, Z=COOMe). This on hydrolysis and opt. methylation gives (I).
申请公布号 DE3788043(D1) 申请公布日期 1993.12.09
申请号 DE19873788043 申请日期 1987.06.13
申请人 TSUMURA & CO., TOKIO/TOKYO, JP 发明人 MATSUOKA, YOSHIYUKI, CHUO-KU TOKYO 103, JP;HOSAKA, KUNIO, CHUO-KU TOKYO 103, JP;TAKEDA, SHIGEHUMI, CHUO-KU TOKYO 103, JP;MITSUHASHI, HIROSHI, CHUO-KU TOKYO 103, JP
分类号 C07D317/68;A61K31/357;A61K31/36;A61P1/16 主分类号 C07D317/68
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