发明名称 |
USE OF N-(2-(DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE AND ITS ANALOGUES FOR CANCER TREATMENT |
摘要 |
2136860 9324096 PCTABS00028 A new treatment schedule for administration of N-¢2-(dimethylamino)ethyl!acridine-4-carboxamide and other related carboxamide anticancer drugs in which the drug is administered in a divided-dose shedule comprising two or more administrations at frequent intervals, for example every hour. Schedules to produce cyclic peaks/troughs in plasma levels are mentioned. The compounds can be used for circumventing multidrug resistance in cancers and may, for example, be used in combination with other cytotoxic drugs, especially non-topo II inhibitors. Treatment of melanoma and advanced colon cancer is included.
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申请公布号 |
CA2136860(A1) |
申请公布日期 |
1993.12.09 |
申请号 |
CA19932136860 |
申请日期 |
1993.05.25 |
申请人 |
XENOVA LTD |
发明人 |
BAGULEY BRUCE C;ATWELL GRAHAM J;DENNY WILLIAM A;FINLAY GRAEME J;REWCASTLE GORDON W |
分类号 |
A61K38/00;A61K31/165;A61K31/195;A61K31/28;A61K31/335;A61K31/40;A61K31/47;A61K31/473;A61K31/475;A61K31/495;A61K31/505;A61K31/535;A61K31/675;A61K31/70;A61K33/24;A61K38/21;A61P35/00;(IPC1-7):A61K38/19;A61K38/14;A61K31/435;A61K31/445;A61K31/555 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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