Processes for producing 2-substituted benzo(beta)thiophene.

摘要

A 2-alkylthiobenzaldehyde of general formula (I) is reacted with a halo compound of general formula (II) to produce a 2-substituted benzo[b]thiophene of general formula (III). <CHEM> wherein R<1> means an alkyl group of 1 to 4 carbon atoms. X<1>CH2Y (II> wherein X<1> means Cl or Br; Y means -CO2H, -CO2R<2>, -COR<2>, -CONH2 or -CN; R<2> means an alkyl group of 1 to 4 carbon atoms. <CHEM> wherein Y is as defined above. The process of this invention is of great economic and industrial value, for 2-acetylbenzo[b]thiophene and 2-benzo[b]thiophenecarboxylic acid, which are important intermediates for drugs and agricultural chemicals among others, can be obtained in a simple manner, easily and in high yield.