| 摘要 |
PURPOSE:To obtain a human parathyroidal hormone (PTH) derivative improved in characteristics of the PTH (1-34). CONSTITUTION:The PTH derivative in which one or more of the 3-, 14-, 15-, 16-, 17-, 25-, 26-, 27-and 34-positions of the PTH (1-43) having an amino acid sequence expressed by the formula are substituted with other amino acid residues. This excellent PTH derivative having characteristics such as an increase in stability to enzymolysis and a rise in activity can be obtained by the substitution. The resultant derivative is capable of providing a medicine useful for osteopathy, etc. |
