发明名称 |
Osteogenic proteins |
摘要 |
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
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申请公布号 |
US5266683(A) |
申请公布日期 |
1993.11.30 |
申请号 |
US19920841646 |
申请日期 |
1992.02.21 |
申请人 |
STRYKER CORPORATION |
发明人 |
OPPERMANN, HERMANN;OZKAYNAK, ENGIN;KUBERASAMPATH, THANGAVEL;RUEGER, DAVID C.;PANG, ROY H. L. |
分类号 |
A61C8/00;A61F2/00;A61K6/00;A61K9/00;A61K38/00;A61K38/18;A61L27/22;A61L27/24;A61L27/34;A61L27/36;A61L27/56;C04B14/12;C04B20/06;C07K14/51;(IPC1-7):A61K37/02;C07K5/00;C07K7/00;C07K15/00 |
主分类号 |
A61C8/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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