| 摘要 |
<p>The subject invention relates to compositions in dosage form comprising a solid dispersion which is a solidified melt mixture consisting essentially of the following components: (a) from about 15 % to about 75 % of tebufelone; (b) from about 25 % to about 65 % of a poloxamer surfactant having a melting point of about 40 °C or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 daltons to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50 % to about 90 % of the copolymer; and (c) from 0 % to about 60 % of other components, wherein the other components are miscible with a melt mixture of components (a) and (b).</p> |
