SOLUBLE PRION POLYPEPTIDES, AND METHODS FOR DETECTING AND PURIFYING THEREOF

摘要

Novel soluble prion polypeptides occurring in vivo, and methods of making and using thereof. Diagnostic methods are also provided having both generality and rapidity for the identification of soluble infectious or normal prion polypeptides in animal or human subjects which provide a diagnosis as to present or future prion-related pathologies, which methods provide relatively simple and commercially useful diagnostic assays which can be applied in the field or in the laboratory for the detection of prion infection in livestock and humans.