发明名称 FUSED IMIDAZOLE AND TRIAZOLE DERIVATIVES AS 5-HT1 RECEPTOR AGONISTS
摘要 Compounds of formula (I) wherein Q represents the residue of a six-membered aromatic or heteroaromatic nucleus containing zero, one or two nitrogen atoms; V represents nitrogen or C-A<2>; E represents a bond or a straight or branched alkylene chain containing from 1 to 4 carbon atoms; F represents a group of formula (a); U represents nitrogen or C-R<2>; B represents oxygen, sulphur or N-R<3>; R<1> represents -CH2.CHR<4>.NR<6>R<7> or a group of formula (i), (ii), (iii) or (iv); are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
申请公布号 WO9323396(A1) 申请公布日期 1993.11.25
申请号 WO1993GB00936 申请日期 1993.05.06
申请人 MERCK SHARP & DOHME LIMITED 发明人 STREET, LESLIE, JOSEPH
分类号 C07D473/02;A61K31/437;A61K31/44;A61K31/52;A61P25/04;A61P25/06;A61P43/00;C07D471/04;C07D473/00;(IPC1-7):C07D471/04;A61K31/435;C07D487/04 主分类号 C07D473/02
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