发明名称 |
METHOD AND REAGENT FOR INHIBITING VIRAL REPLICATION |
摘要 |
Enzymatic RNA molecules which specifically cleave a picornavirus RNA, an immunodeficiency virus RNA in a gene required for viral replication, e.g., the vif, nef, tat or rev gene regions, RNA of a hepatitis virus, T-cell leukemia virus RNA, RNA of a hepatitis C virus, mRNA or rhRNA of a cytomegalovirus, an influenza virus RNA, and a herpes simplex virus mRNA molecule; and methods and reagents useful in selection and optimization of ribozymes. In particular, the enzymatic RNA molecule is formed in a hammerhead motif, in the motif of a hairpin, hepatitis delta virus, group I intron or RNaseP-like RNA. The figure is a diagrammatic representation of an enzymatic RNA molecule in the hammerhead motif. |
申请公布号 |
WO9323569(A1) |
申请公布日期 |
1993.11.25 |
申请号 |
WO1993US04020 |
申请日期 |
1993.04.29 |
申请人 |
RIBOZYME PHARMACEUTICALS, INC. |
发明人 |
DRAPER, KENNETH, G.;DUDYCZ, LECH, W.;MCSWIGGEN, JAMES, A.;MACEJAK, DENNIS, G.;HOLECEK, JAMES, J.;MAMONE, J., ANTHONY |
分类号 |
C12N15/09;A61K31/70;A61K38/00;A61K38/43;A61K39/125;A61K39/13;A61K39/135;A61K39/145;A61K39/21;A61K39/23;A61K39/245;A61K39/29;A61K48/00;A61P1/16;A61P31/12;A61P31/14;A61P31/16;A61P31/18;A61P31/22;A61P35/02;C07H19/06;C07H21/02;C07K14/08;C12N5/10;C12N7/00;C12N9/00;C12N9/22;C12N15/10;C12N15/113;C12N15/85;C12N15/86;C12Q1/68;C12Q1/70;C12R1/91;C12R1/93;G01N33/569 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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