ALTERATION OF THE INTERACTION OF THE CD4 T-CELL RECEPTOR WITH AN RAF-1-RELATED PROTEIN

摘要

Methods for screening candidate compounds to identify compounds capable of inhibiting the naturally occurring association of the anti-Raf-1 precipitable 110 Kd phosphoprotein p110 and the CD4:p56 T cell receptor complex, or capable of inhibiting intracellular signalling through this complex; and a substantially pure preparation of p110.