| 摘要 |
Staurosporin derivatives of the formula I are described, <IMAGE> (I) in which R1 is hydrogen, hydroxyl, lower alkoxy or oxo and R2 is a radical of the formula II <IMAGE> (II) in which the configuration of the sugar moiety is derived from D-glucose, D-galactose or D-mannose, and R3-R7 are as defined below. These compounds have a pronounced and selective inhibitory action on the enzyme proteinkinase C and have, inter alia, an antitumor action.
|
