| 摘要 |
<p>PURPOSE:To obtain a new polypeptide having inhibitory action on coagulation of thrombin and blood platelet aggregation and/or promoting action on protein C activation of thrombin. CONSTITUTION:In an amino acid sequence of human thrombomodulin, an amino acid residue playing an important role in bonding to thrombin when a promoting action on activation of protein C with thrombin develops, is identified to prepare a thrombomodulin having integrity of various strength. Since the polypeptide has inhibitory action on coagulation of thrombin and blood platelet aggregation and/or promoting action on protein C activation of thrombin, the polypeptide is useful as a medicine or treating and preventing diseases followed by coagulation.</p> |
