发明名称 |
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摘要 |
New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms. |
申请公布号 |
JPH05306271(A) |
申请公布日期 |
1993.11.19 |
申请号 |
JP19920289958 |
申请日期 |
1992.10.28 |
申请人 |
ELI LILLY & CO;UNIV HAWAI |
发明人 |
ROZANNU BONJIYOUKURIAN;RICHIYAADO ERIOTSUTO MUUA;GUREGORII MASHIYUU REON PATAASON;TEIMU AREN SUMITOKA |
分类号 |
A61K31/40;A01N43/38;A01N43/90;A61K31/403;A61P31/04;A61P35/00;C07D209/56;C07D209/70;C07D209/80;C07D491/06;C07D491/08;C12N1/12;C12P17/08;C12P17/10;C12P17/18;C12R1/89;(IPC1-7):C07D209/56 |
主分类号 |
A61K31/40 |
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