HUMAN TYPE MONOCLONAL ANTIBODY AND GENE CODING THE SAME, HYBRIDOMA AND ANTITUMOR AGENT

摘要

PURPOSE:To provide the novel monoclonal antibody useful for producing an antitumor agent by bonding the antibody to a liposome in which a carcinostatic agent is emcapsuled. CONSTITUTION:The human type monoclonal antibody, e.g. GAH antibody (IgG), is produced by the cell fusion of a cancer patient-originated lymphocyte with a mouse myeloma cell, and specifically binds to the membrane surface antigen of a cancer cell. An example of antigen is produced by culturing a hybridoma GAH prepared by fusing the mouse myeloma cell with the lymphocyte originated from a lymph node belonging to the cancer site of the cancer patient.