Verfahren zur Herstellung von 2-beta-substituierten-Methyl-penicillinderivaten.

摘要

A process for preparing a 2 beta -substituted-methylpenicillin compound of the formula wherein -N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula wherein R1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula wherein is as defined above in the presence of a metal compound. n