摘要 |
<p>The invention discloses the use of an active compound of the formula : <CHEM> wherein : either <a) R<1> is NHR<4>, NR<4>R<5> or OH and R<3> is hydrogen or <b) R<3> is NHR<4>, NR<4>R<5> or OH and R<1> is hydrogen ; R<2> is hydrogen or C1-4 lower alkyl ; R<4> is hydrogen, hydroxyl or C1-4 lower alkyl ; and R<5> is C1-4 lower alkyl ; provided that when R<1> is OH, R<2> is methyl, and provided that when R<3> is N(CH3)2 or OH, R<1> and R<2> cannot both be hydrogen or a pharmaceutically acceptable salt or hydrate thereof for the manufacture of a medicament for treating a tumor in a mammal, as well as new compounds, of the formula (I) except the compound wherein R<1> is OH, R<2> is methyl and R<3> is hydrogen and the corresponding pharmaceutical composition.</p> |