SALTS OF 3-(CIS-2,6-DIMETHYLPIPERIDINO)SYDNONE IMINE

摘要

23233-276 The present invention relates to 3-(cis-2,6-dimethylpiperidino)sydnone imine salts of the general formula I. (I) in which X denotes H2PO4 or processes for their preparation and their use. The salts of formula I are not hygroscopic, which makes them more suitable for the preparation of pharmaceutical compositions. In aqueous solutions they set a weakly acidic pH, favourable for the stability of the sydnone imine and acceptable for parenteral administration. They lower the blood pressure, the pulmonary artery pressure and the left ventricular end-diastolic pressure, without provoking reflex tachycardia, thus being useful in the control or prevention of disorders of the cardiovascular system.