ISOXAZOLE-BETA-CARBOLINE DERIVATIVES

摘要

(1) B-Carbolines of general Formula I I, wherein Y represents the residue or and Ra and Rb, being identical or different, mean respectively hydrogen, C1-6-alkoxy, phenyl, C3-7-cyclo alkyl, optionally substituted C1-6-alkyl or C1-6-alkoxycarbonyl, and Rc and Rd, being identical or different, mean respectively hydrogen or C1-6-alkyl or jointly a linkage, and R4 is hydrogen, C1-6-alkyl or C1-6-alkoxy-C1-6-alkyl and R5 is hydrogen, halogen, OR6, NR7R8 or CH R9R10 wherein R6 means C1-6-alkyl, C3-7-cycloalkyl or an optionally substituted aralkyl, aryl or hetaryl residue, R7 and R8, being identical or different, (2) represent hydrogen, C1-6-alkyl, C3-6-alkenyl, or jointly with the nitrogen atom a saturated heterocyclic five- or six-membered ring which optionally contains a further hetero atom, R9 means hydrogen or C1-6-alkyl, R10 means hydrogen, C1-6-alkyl, OR11 or NR12R13 wherein R11 means C1-6-alkyl, R12 and R13 are identical or different and mean hydrogen, C1-6-alkyl or jointly with the nitrogen atom a saturated heterocyclic five- or six-membered ring optionally containing a further hetero atom provided that when R5 and R4 are hydrogen, Y is other than 3-methyl-isoxazol-5-yl, and useful to treat epilepsy or anxiety.