发明名称 |
LIGAND FOR THE C-KIT RECEPTOR AND METHODS OF USE THEREOF |
摘要 |
2133982 9321936 PCTABS00027 A pharmaceutical composition which comprises the c-kit ligand (KL) purified by applicants or produced by applicants' recombinant methods in combination with other hematopoietic factors and a pharmaceutically acceptable carrier is provided as well as methods of treating patients which comprise administering to the patient the pharmaceutical composition of this invention. This invention provides combination therapies using c-kit ligand (KL) and a purified c-kit ligand (KL) polypeptide, or a soluble fragment thereof and other hematopoietic factors. It also provides methods and compositions for ex-vivo use of KL alone or in combination therapy. A mutated KL antagonist is also described. Such an antagonist may also be a small molecule. Antisense nucleic acids to KL as therapeutics are also described. Lastly, compositions and methods are described that take advantage of the role of KL in germ cells, mast cells and melanocytes.
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申请公布号 |
CA2133982(A1) |
申请公布日期 |
1993.11.11 |
申请号 |
CA19932133982 |
申请日期 |
1993.04.16 |
申请人 |
SLOAN KETTERING INST CANCER |
发明人 |
BESMER PETER;BUCK JOCHEN;MOORE MALCOLM A S;NOCKA KARL |
分类号 |
A61K38/00;A61K35/16;A61K35/26;A61K38/17;A61K38/18;A61K38/19;A61K38/21;A61K48/00;A61P7/00;A61P7/06;A61P9/00;A61P11/00;A61P17/00;A61P19/00;A61P25/00;A61P27/02;A61P27/14;A61P29/00;A61P31/12;A61P35/00;A61P35/02;A61P37/00;A61P37/08;A61P43/00;C07K14/71;C07K14/715;C12N5/06;(IPC1-7):C12N5/10;C07H21/00;A61D19/02;C12N5/02;A61K35/14;A61K35/28;A61B17/43;C07K14/53;C12N15/87 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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