发明名称 4-IMIDOMETHYL-1-[2'PHENYL-2'OXOETHYL-]PIPERIDINES AS SEROTONIN 5HT2-ANTAGONISTS, THEIR PREPARATION AND USE IN THERAPY
摘要 The present invention is directed to a new class of serotonin 5HT2 antagonists of formula (I) and their use in the treatment of a variety of diseases, in which R is represented by hydrogen, halog- en, C1-4 alkyl, C1-4 alkoxy, -CF3, -OH, or -COF3; and A is repre- sented by one of the following imide derivatives in which R1 and R2 are each independently represented by (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, -CF3, -OH, or -OCF3; and the pharmaceutically acceptable salts there- of.
申请公布号 CA2134077(A1) 申请公布日期 1993.11.11
申请号 CA19932134077 申请日期 1993.03.24
申请人 MERRELL DOW PHARMA 发明人 NIEDUZAK THADDEUS R;DUDLEY MARK W;KEHNE JOHN H
分类号 A61K31/4427;A61K31/445;A61K31/454;A61K31/473;A61K31/517;A61P7/02;A61P25/00;A61P43/00;C07D401/06;(IPC1-7):C07D401/06;A61K31/435;A61K31/505 主分类号 A61K31/4427
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