1-PIPERAZINEACETIC DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS

摘要

The invention thus provides the compounds of general formula (I) and salts, solvates and pharmaceutically acceptable derivatives thereof, in which X?1 and X2¿ represent CH or are different and represent CH or N; Y?1, Y2, Y3 and Y4¿ represent CH, or Y?1 and Y4¿ represent CH and Y?2 and Y3¿ represent N, or Y?2 and Y3¿ represent CH and Y?1 and Y4¿ represent N, or three of Y1 to Y4 represent CH and the other represents N; Z1 represents CH or N; Z2 represents N or N+R6; R1 represents a hydrogen atom or a hydroxyl, C¿1-4?alkyl or 2,2,2-trifluoroethyl group; R?2¿ represents a hydrogen atom or, when both X?1 and X2¿ represent CH, may also represent a fluorine, chlorine or bromine atom or a C¿1-4?alkyl group; R?3¿ represents a hydrogen atom or, when both Y?1 and Y2¿ represent CH, may also represent a fluorine, chlorine or bromine atom or a C¿1-4?alkyl group; R?4 and R5¿ each represent a hydrogen atom; or, when Z1 represents CH and Z2 represents N, R4 may also represent C¿1-4?alkyl; or, when both Z?1 and Z2¿ both represent N, R?4 and R5¿ may be the same or different, and represent hydrogen or C¿1-4?alkyl; R?6¿ represents a C¿1-4?alkyl group or phenylC1-3alkyl group; R?7¿ represents a hydrogen atom; a C¿1-4?alkyl group; a naphthyl group; a thiophene group; an unsubstituted phenyl group; a phenyl group substituted by C1-4alkyl group, C1-4alkoxy, phenylC1-3alkoxy, OH, halogen (where halogen is fluorine, chlorine, bromine or iodine), CF3, unsubstituted phenyl, phenyl substituted by OH, pyridinyl, NR?8R9¿, NHSO¿2?R?8, CONR8R9¿ or CO¿2R?8; a C¿1-4?alkyl group substituted by one or more naphthyl, phenyl, OH or CO2R?8¿; a C¿2-4?alkenyl group substituted by one or more naphthyl, phenyl, OH or CO2R?8¿; or a saturated or unsaturated C¿5-7?cycloalkyl group; and R?8 and R9¿, which may be the same or different represent H or C¿1-4?alkyl or, together with the nitrogen atom to which they are attached, form a saturated 5 to 7 membered ring.