发明名称 |
BYSTANDER EFFECT TUMORICIDAL THERAPY |
摘要 |
A method for treating a tumor involves the initial identification of the tumor as one displaying a "bystander effect", whereby in vivo transfer of a gene conferring sensitivity to chemotherapeutic agent affects both transformed and non-transformed tumor cells. Into a tumor thus characterized is introduced in situ a retroviral vector containing the sensitizing gene. The retroviral vector, which may be a replication-defective or a replication-competent, can be introduced directly (if it is replication-competent) or can be provided by means of a packaging cell line. Treatment of the patient with the chemotherapeutic agent thereafter effects tumor regression when as few as 10 % of tumor cells are transformed, while normal tissue is not damaged. The anti-tumor impact of the treatment can be increased when the transducing vector also encodes an immune response-enhance substance such as IL-2 or another cytokine. |
申请公布号 |
WO9321959(A1) |
申请公布日期 |
1993.11.11 |
申请号 |
WO1993US04002 |
申请日期 |
1993.05.03 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH |
发明人 |
CULVER, KENNETH, W.;BLAESE, R., MICHAEL |
分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K38/00;A61K38/21;A61K38/45;A61K39/00;A61K48/00;A61P35/00;A61P37/06;C07H21/04;C12N5/10;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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