QUINOLINE DERIVATIVE OR SALT THEREOF AND REMEDY FOR CARDIAC DISEASES CONTAINING THE SAME

摘要

A quinoline derivative represented by general formula (1), a medicinally acceptable salt thereof, and a remedy for cardiac diseases containing the same, wherein ring A represents a furan, dihydrofuran or dioxolane ring, R<1> represents hydroxy, carboxy, alkoxycarbonyl, etc., R<2>s may be the same or different from each other and each represents hydrogen, alkyl, etc., R<3> and R<4> may be the same or different from each other and each represents hydrogen, halogen, alkyl, amino, alkoxy, etc., R<5>, R<6>, R<7> and R<8> may be the same or different from one another and each represents hydrogen or alkyl, m represents an integer of 0 to 3, and symbol ...... means that there may be a double bond formed by R<6> and R<8>. The compound (1) has a positively inotropic effect on myocardia and an antiarrhythmic effect and can dilate blood vessels without extremely increasing the heart rate. Therefore, a remedy for cardiac diseases containing the same as the active ingredient is remarkably useful for treating cardiac insufficiency, arrhythmia, and so forth.