发明名称 Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
摘要 A method of treating open-angle glaucoma consisting of providing to the trabecular meshwork a substance such as MMP-1, MMP-2, MMP-3, basic heparin-binding growth factor, nerve growth factor, Interleukin-1, Interleukin-6, TPA, Ca++, Zn++, plasmin, trypsin, and APMA in effective amount to lower intraocular pressure is provided. A method of treating retinal disease such as; retinal degeneration, ocular neovascularization, and diabetic retinopathy consisting of providing to the optic cup a TIMP, retinoic acid, Razoxane, EDTA, EGTA or 1,10-phenanthrolie in an effective amount to ameliorate the retinal disease is also provided.
申请公布号 US5260059(A) 申请公布日期 1993.11.09
申请号 US19890338305 申请日期 1989.04.14
申请人 THE STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON HEALTH SCIENCES UNIVERSITY 发明人 ACOTT, TED S.;ALEXANDER, J. PRESTON;BRADLEY, JOHN M. B.
分类号 A61K31/00;A61K31/12;A61K31/31;A61K33/06;A61K33/30;A61K38/18;A61K38/20;A61K38/48;A61K38/55;C07K16/38;C07K16/40;(IPC1-7):A61K37/54;C12N9/64 主分类号 A61K31/00
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