发明名称 |
Guanidine derivatives compositions and use |
摘要 |
Compounds of the formula <IMAGE> I wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
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申请公布号 |
US5260307(A) |
申请公布日期 |
1993.11.09 |
申请号 |
US19910719429 |
申请日期 |
1991.06.24 |
申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
ACKERMANN, JEAN;BANNER, DAVID;GUBERNATOR, KLAUS;HADVARY, PAUL;HILPERT, KURT;MUELLER, KLAUS;LABLER, LUDVIK;SCHMID, GERARD;TSCHOPP, THOMAS B.;WESSEL, HANS P.;WIRZ, BEAT |
分类号 |
A61K31/445;A61K31/4427;A61K31/4433;A61K31/47;A61K31/535;A61K31/5375;A61K31/55;A61P7/02;A61P35/00;C07D;C07D211/20;C07D211/22;C07D211/26;C07D211/60;C07D265/30;C07D265/32;C07D401/12;C07D401/14;C07D409/12;C07D409/14;C07D413/12;(IPC1-7):A61K31/445 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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