发明名称 |
Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia |
摘要 |
The present invention provides pyrazines, pyridazines or pyrimidines, or salts or prodrugs thereof, substituted on one of the ring carbon atoms thereof with a non-aromatic azacyclic or azabicyclic ring system; and independently substituted on each of the other ring carbon atoms with a substituent of low lipophilicity or a hydrocarbon substituent; which compounds stimulate central muscarinic acetylcholine receptors and therefore are useful in the treatment of neurological and mental illnesses.
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申请公布号 |
US5260293(A) |
申请公布日期 |
1993.11.09 |
申请号 |
US19910775630 |
申请日期 |
1991.10.10 |
申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
BAKER, RAYMOND;STREET, LESLIE J.;SAUNDERS, JOHN |
分类号 |
C07D401/04;C07D403/04;C07D403/12;C07D451/02;C07D453/02;C07D453/06;C07D471/08;C07D487/04;(IPC1-7):A61K31/55;A61K31/495;A61K31/50;C07D413/04;C07D209/52 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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