发明名称 |
Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives |
摘要 |
A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
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申请公布号 |
US5260288(A) |
申请公布日期 |
1993.11.09 |
申请号 |
US19920863179 |
申请日期 |
1992.04.03 |
申请人 |
THE BIOMEMBRANE INSTITUTE |
发明人 |
IGARASHI, YASUYUKI;RUAN, FUGIANG;SADAHIRA, YOSHITO;KAWA, SHIGEYUKI;HAKOMORI, SEN-ITIROH |
分类号 |
A61K31/66;A61P35/00;C07F9/10;C07F9/113;C07F9/173;(IPC1-7):A61K31/66 |
主分类号 |
A61K31/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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