Lipid-A analogs: New monosaccharide and disaccharide intermediates for eliciting therapeutic antibodies and for antitumor and antiviral activities

摘要

Compounds are disclosed that are useful for eliciting antibodies which bind to Lipid-A, induce protective immunity against gram-negative bacterial infection, protect against viral infection, control tumor growth, and bind to receptors in competition with Lipid-A. Compositions containing these compounds are also disclosed. Further, antibodies elicited by the compounds are disclosed, as well as uses for such antibodies, for instance in treating septicemia.