发明名称 |
CHLOROPHYLL AND BACTERIO-CHLOROPHYLL DERIVATIVES, METHOD FOR PRODUCING THEM AND MEDICAL PREPARATIVES CONTAINING SAID COMPOUNDS |
摘要 |
Conjugates of chlorophyll (Chl) and bacteriochlorophyll (Bchl) derivatives with amino acids, peptides and proteins are provided by the invention.The amino acid, peptide or protein residue is linked to the 17-propionic acid group of a Chl or Bchl residue directly or through a chain.The conjugates are for use as photosensitizers in photodynamic therapy and in diagnostics of tumors. Conjugation with cell-specific ligands, such as hormones, growth factors or tumor-specific antibodies, will target the Chl or Bchl moiety to the tumor site. Thus, conjugates with melanocyte stimulating hormones are suitable for photodynamic therapy of melanoma tumors. |
申请公布号 |
HU9302149(D0) |
申请公布日期 |
1993.10.28 |
申请号 |
HU19930002149 |
申请日期 |
1993.07.23 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE,IL |
发明人 |
AVIGDOR,SCHERZ,IL;YORAM,SALOMON,IL;LESZEK,FIEDOR,PL |
分类号 |
A61K31/555;A61K38/00;A61K38/22;A61K39/395;A61K41/00;A61K47/48;A61K49/00;A61N5/06;A61P35/00;A61P43/00;C07D487/22;C07K1/113;C07K5/023;C07K14/575;C07K14/685;C07K14/795;C07K16/00;C12N9/18;C12P17/18;G01N33/50;G01N33/574 |
主分类号 |
A61K31/555 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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