| 摘要 |
<p>Processing of β-amyloid precursor protein (βAPP) is monitored by detecting the secretion of a soluble bAPP fragment resulting from cleavage of βAPP at the amino-terminus of β-amyloid peptide. in vivo monitoring of secretion of the βAPP fragment may be monitored for diagnosis and prognosis of Alzheimer's disease and other β-amyloid-related diseases, while in vitro monitoring of such secretion from cultured cells may be monitored to identify inhibitors of β-amyloid production. The βAPP fragment may be detected using antibodies and other specific binding substances which recognize a carboxy-terminal residue on the fragment.</p> |
