发明名称 |
METHODS AND COMPOSITIONS FOR MONITORING CELLULAR PROCESSING OF beta -AMYLOID PRECURSOR PROTEIN |
摘要 |
Processing of beta -amyloid precursor protein ( beta APP) is monitored by detecting the secretion of a soluble bAPP fragment resulting from cleavage of beta APP at the amino-terminus of beta -amyloid peptide. in vivo monitoring of secretion of the beta APP fragment may be monitored for diagnosis and prognosis of Alzheimer's disease and other beta -amyloid-related diseases, while in vitro monitoring of such secretion from cultured cells may be monitored to identify inhibitors of beta -amyloid production. The beta APP fragment may be detected using antibodies and other specific binding substances which recognize a carboxy-terminal residue on the fragment. |
申请公布号 |
WO9321526(A1) |
申请公布日期 |
1993.10.28 |
申请号 |
WO1993US01817 |
申请日期 |
1993.03.03 |
申请人 |
ATHENA NEUROSCIENCES, INC.;ELI LILLY AND COMPANY |
发明人 |
SEUBERT, PETER, A.;SCHENK, DALE, B.;FRITZ, LAWRENCE, C. |
分类号 |
G01N33/53;C07K14/47;C07K16/00;C07K16/18;C12N15/02;C12N15/85;C12P21/08;C12R1/91;G01N33/50;G01N33/68;(IPC1-7):G01N33/53;C07K15/00;C07K13/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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