A delivery system for biologicaly active growth or morphogenetic factors and a method for preparing such delivery system

摘要

A method of preparing a delivery system for a biologically active growth and morphogenetic factor by using chromatographic techniques and which includes introducing such biologically active factor into a chromatography column of appropriate dimensions which contains an integral porous carrier comprising a solid adsorbent selected for its specific affinity for such biologically active factor. In one embodiment of the invention, porous hydroxyapatite is used as the carrier for bone morphogenetic proteins (i.e. BMPs). The invention extends to a delivery system prepared according to the above method; to an apparatus for preparing the delivery system according to this method; and to use of the delivery system in a method for inducing the information of new bone in primates.