| 摘要 |
<p>A peptide represented by the sequence (I), a pulmonary surfactant comprising the peptide and a lipid mixture, and a remedy for respiratory distress syndrome containing the surfactant as the active ingredient. In sequence (I) Xaa means the absence of any member or represents Cys, Ser or Ala; Xbb represents Cys, Ser or Ala; Xcc represents His or Asn; Xdd represents Leu or Ile; Xee represents Val or Ile; Xff represents Ile, Leu or Val; and Xgg means the absence of any member or represents Leu. The peptide is easy to isolate and purify, can be mass produced in a short time and has a potent surface activity when mixed with a lipid mixture. The pulmonary surfactant has a good suspending activity and a potent surface activity, thus being useful as a remedy for respiratory distress syndrome.</p> |
