INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS

摘要

A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, furyl or thienyl, all of which may be optionally substitued by halo, C1-C4 alkyl, C1-C4 alkoxy or a group of the formula: -X-R<2>; R<1> is H, C1-C6 alkyl, C3-C7 cycloalkyl, C5-C7 cycloalkenyl, C3-C6 alkenyl or C3-C6 alkynyl, said alkyl group being optionally substituted by C3-C7 cycloalkyl, C3-C7 cycloalkyloxy, OH, C1-C6 alkoxy, CONR<3>R<4>, SO2NR<3>R<4>, COR<5>, SOR<5>, SO2R<5>, CO2R<6>, aryl, aryloxy, aryl(C1-C6)alkoxy or heteroaryl, said alkenyl group being optionally substituted by aryl and said cycloalkyl group being optionally substituted by OH; the cycloalkyl and cycloalkenyl groups of the foregoing groups being optionally linked to the N-atom by a C1-C2 alkylene moiety; R<2> is COR<7>, CO2R<7>, SOR<7>, SO2R<7>, CONR<3>R<4>, SO2NR<3>R<4>, NHCOR<7>, NHCONR<3>R<4>, NHSO2R<7>, NHSO2NR<3>R<4>, OH or CN; R<3> and R<4> are either each independently selected from H, C3-C7 cycloalkyl and C1-C6 alkyl, said alkyl group being optionally substituted by C3-C7 cycloalkyl or aryl, or R<3> and R<4> taken together represent C3-C6 alkylene optionally interrupted by O, S(O)n, NH or N(C1-C6 alkyl); R<5> is C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C6)alkylene, aryl(C1-C6)alkylene or aryl; R<6> is C1-C6 alkyl, C3-C7 cycloalkyl or aryl(C1-C6)alkylene; R<7> is C1-C6 alkyl; X is a direct link or C1-C7 alkylene; m is 1 or 2; and n is 0, 1 or 2; are selective 5-HT1-like receptor agonists useful in the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.