发明名称 |
TRANSDERMAL DRUG DELIVERY SYSTEM |
摘要 |
A multidose transdermal drug delivery assembly comprises a laminate composite having a plurality of reservoirs (7) formed therein. Unit doses with transdermal drug actives for transdermal administration are disposed in the reservoirs. Individual seals (5) enclose the drug in each of the reservoirs. The unit doses are in the form of a multiphase composition of microspheres wherein an internal phase comprises the drug actives and adjuvants surrounded by an outer phase of film-forming polysaccharides engrafted with transdermal promoters. The microspheres are distributed through a diffusable matrix for the composition. The individual seals (5), upon activation, disrupt the microspheres (8) to release the drug actives and adjuvants in the unit dose compartment (7), and the drug diffuses through the matrix to a patient's skin. A security strip (14) may be provided to prevent accidental activation of the drug. |
申请公布号 |
WO9320787(A1) |
申请公布日期 |
1993.10.28 |
申请号 |
WO1993US03088 |
申请日期 |
1993.03.26 |
申请人 |
D'ANGELO, JOSEPH;SCHUR, HENRY |
发明人 |
D'ANGELO, JOSEPH;SCHUR, HENRY |
分类号 |
A61K9/70;A61M37/00;(IPC1-7):A61F13/00 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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