发明名称 |
MONOCYTE ADHESION PROTEIN AND MONOCLONAL ANTIBODY THERETO |
摘要 |
This invention relates to a method for the prevention of monocyte adherence to the endothelial cells lining blood vessels, their subsequent invasion of surrounding tissues and diseases related thereto. It comprises inducing a monocyte adhesion protein to the surface of endothelial cells by treatment with specific cytokines, preparing a monoclonal antibody to the monocyte adhesion protein and contacting the antibody to the protein to form a complex. The monoclonal antibody does not bind to the cell surface proteins VCAM or ELAM. The complex results in a decrease in the adherence of monocytes to endothelial cells and thereby attenuates or prevents the harmful effects of monocyte invasion of endothelial cells and surrounding tissues. |
申请公布号 |
WO9320830(A1) |
申请公布日期 |
1993.10.28 |
申请号 |
WO1993US03433 |
申请日期 |
1993.04.12 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNI |
发明人 |
BERMAN, JOAN, W.;CALDERON, TINA, M. |
分类号 |
A61K38/00;C07K16/28;(IPC1-7):A61K35/14;A61K45/05;C12N15/00;C12N5/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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