发明名称 |
Process for the preparation of etoposide phosphate and intermediates thereof. |
摘要 |
<p>An etoposide phosphate represented by the formula (1): <CHEM> is prepared by blocking the hydroxyl groups of the saccharide moiety of etoposide with halogenoacetyl groups, thereafter phosphorylating the 4'-position, and removing the halogenoacetyl groups from the obtained phosphate in the presence of an amine. This precess can give the objective etoposide phosphate in a higher yield than that of the prior art to enable the industrial mass-production thereof.</p> |
申请公布号 |
EP0567089(A1) |
申请公布日期 |
1993.10.27 |
申请号 |
EP19930106446 |
申请日期 |
1993.04.21 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
YOSHINOBU, MIYAZAWA;HITOSHI, SATO;HIROSHI, YOSHIKAWA;KOUICHI, OHKAWA;NORIKO, TOMIYOSHI |
分类号 |
C07H17/04;(IPC1-7):C07H17/04;A61K31/70 |
主分类号 |
C07H17/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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