发明名称 |
Benzoxazepine derivatives as cholinesterase inhibitors. |
摘要 |
<p>A compound of the formula: <CHEM> wherein ring A is an optionally substituted benzene ring; ring B' is an optionally substituted non-aromatic heterocyclic ring having, the same or different, two or more hetero atoms; R<1> is a hydrogen atom or an optionally substituted hydrocarbon group, which may be different from one another in the repetition of n; Y is an optionally substituted amino group or an optionally substituted N-containing saturated heterocyclic group; n denotes an integer of 1 to 10, provided that when the ring B' is a 5- to 7-membered ring, the ring B' contains at least one nitrogen atom as hetero atom and n denotes an integer of 2 to 10, or a salt thereof. The compounds and salts thereof have an excellent cholinesterase inhibitory activity and antidepressant activity, and are useful as therapeutic and/or prophylactic medicaments of senile dementia.</p> |
申请公布号 |
EP0567090(A2) |
申请公布日期 |
1993.10.27 |
申请号 |
EP19930106448 |
申请日期 |
1993.04.21 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
GOTO, GIICHI;MIYAMOTO, MASAOMI;ISHIHARA, YUJI |
分类号 |
C07D263/58;C07D267/14;C07D413/06;(IPC1-7):C07D267/14 |
主分类号 |
C07D263/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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