| 摘要 |
PURPOSE:To obtain industrially and advantageously the subject compound useful as a synthetic intermediate for medicines, agricultural chemicals and dye by treating a specific nitrogen-containing six-membered compound with cells of a microorganism or its treated material in the presence of phenazine methosulfate in an aqueous medium. CONSTITUTION:A nitrogen-containing six-membered compound (e.g. nicotinic acid) of formula I (R<1> is carboxyl, carbamoyl, cyano, formyl, 1-5C hydroxyalkyl, etc.; R<2> is H or carboxyl; A is C or N) is treated with cells of microorganism belonging to the genus Agrobacterium, Arthrobacter, Bordetella, Brevibacterium, Pseudomonas, Achromobacter, Comamonas, Erwinia, Bacterium, Corynebacterium, Serratia, Sarcina, etc., or its treated material in the presence of phenazine methosulfate in an aqueous medium to give a 6-hydroxy nitrogen- containing six-membered compound (e.g. 6-hydroxynicotinic acid) of formula II. |
