Processes of converting taxanes into 10-deacetylbaccatin III
摘要
A process for the preparation of a compound of formula (I) <IMAGE> comprising contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction solvent in the presence of a Lewis acid.
申请公布号
US5256801(A)
申请公布日期
1993.10.26
申请号
US19920986852
申请日期
1992.12.04
申请人
NAPRO BIOTHERAPEUTICS, INC.
发明人
CARVER, DAVID R.;PROUT, TIMOTHY R.;EWALD, HERNITA A.;HENDERSON, DONIA L.
