发明名称 |
3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents |
摘要 |
The present invention is novel compounds which are 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted 1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and 1,2,4-triazoles, and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.
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申请公布号 |
US5256680(A) |
申请公布日期 |
1993.10.26 |
申请号 |
US19920906255 |
申请日期 |
1992.06.29 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
CONNOR, DAVID T.;FLYNN, DANIEL L.;KOSTLAN, CATHERINE R.;MULLICAN, MICHAEL D.;SHRUM, GARY P.;UNANGST, PAUL C.;WILSON, MICHAEL W. |
分类号 |
C07D249/12;C07D249/14;C07D271/06;C07D271/07;C07D271/10;C07D271/113;C07D285/08;C07D285/12;C07D285/125;C07D285/13;C07D285/135;(IPC1-7):C07D271/10;C07D27/113;A61K31/41 |
主分类号 |
C07D249/12 |
代理机构 |
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代理人 |
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地址 |
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